Topic: The role of histone acetylation and other histone modifications in enhancer function.

A position as postdoctoral fellow in molecular biology is vacant at the Department of Molecular Biology (www.uib.no/en/mbi). The position is for a period of 3 years and is funded by the Norwegian Cancer Society. The position is associated with the group of professor Rein Aasland and is part of the intradepartmental research programme NucReg which focuses on molecular interactions, their regulation and function in relation to gene regulation and transcriptional responses. (http://www.uib.no/en/rg/nucreg and http://www.uib.no/en/mbi).

About the project

Topic for the project is the molecular mechanisms for enhancer function in the context of regulation of gene expression in normal cells and during development of cancer. The role of histone acetylation and other histone modifications in the communication between enhancers and promoters is a key question. The project builds on data from a proteomic screen which implicates several protein complexes and new proteins in enhancer function. Approaches in the project will include CRISPR/Cas9, ChIP, and knock-down).

Qualification requirements include:

• The applicant must hold a Norwegian PhD or an equivalent degree within molecular biology or molecular cell biology or have submitted his/her doctoral thesis for assessment prior to the application deadline. It is a condition for employment that the PhD has been awarded.
• Successful applicants must have experience with cell culture and genetic engineering. Experience with modern molecular genetic methods will be emphasized.
• Interest for and experience with research on gene regulation or chromatin is an advantage.

Application instructions:

Please consult the full advertisement of the position on Jobbnorge.no and observe that only applications submitted through this website are accepted    https://www.jobbnorge.no/en/available-jobs/job/120751

NBS-Oslo inviterer til Generalforsamling og populærvitenskapelig foredrag:

«Matfrykt og matfakta – skremslenes anatomi»
Med Trygve Eklund
Trygve Eklund har teknisk doktorgrad fra Lunds Universitet, cand.real-grad fra UiO, og MBA fra BI – og er tilkjent professorkompetanse i matvitenskap.
Tirsdag 8. desember
Kristine Bonnevies Hus, Universitetet i Oslo
Kl 15:15, Auditorium 1

Etter seminaret blir det Generalforsamling:

Rom 3213, Kristine Bonnevies hus kl 1615.
Etter generalforsamlingen serverer vi tapas.

Kort om foredraget:
Matfrykt er blitt et gjennomgående tema i medier. Mer eller mindre bevisst uvitenhet ligger til grunn for at bøker blir skrevet og nettsteder florerer med såkalte ”avsløringer” av risikofaktorer i mat. De ukyndiges selvbevisste utfoldelse skremmer bokstavelig talt vettet av folk, og vitenskapelig funderte synspunkter kommer lite frem i lyset.
Nærværende foredragsholder, som liker å kalle seg ”kunnskapsformidler og kåsør”, har 30 års erfaring knyttet til arbeid med risikofaktorer i mat og miljø. Ubundet av forretningsinteresser, myndighetsunderdanighet og politisk korrekthet vil han gjennomgå grunnlaget for matfrykt, med særlig vekt på tilsetningsstoffer.

Enhet for vevskultur, regenerativ medisin har som sitt forskningsmål å utvikle et optimalt system for lagring av dyrkede celler med det formål å utvide adgangen til regenerativ medisin. For å fremme effektiv transplantasjon av lagrede, dyrkede vev tester vi at vevets grunnleggende karakter er uendret etter lagring; viabilitet, fenotype og morfologi.
Vi søker en erfaren og motivert post-doc for stillingen som forsker. Stillingen er et vikariat i 100 % med 1 års varighet. Det er mulighet til forlengelse/fast ansettelse for en god kandidat med eksepsjonelle ferdigheter. Vi søker etter en entusiastisk og målrettet person som kan arbeide selvstendig så vel som i samarbeid med vårt team.

Søknader sendes via e-post til [email protected].
Kandidater som blir utvalgt for intervju vil bli kontaktet av søkerkomiteen.

Read more

Title: Guiding signals through anchored enzyme complexes: implications for disease

Abstract: Intracellular signal transduction events are precisely regulated in space and time. This is achieved in part by A-Kinase Anchoring Proteins (AKAPs) that tether a variety of protein kinases and phosphatases in proximity to selected substrates. AKAP targeting provides an efficient means to reversibly control the phosphorylation status of key substrates and contributes to the dynamic regulation of sophisticated cellular pathways. Using biochemical, genetic, and super-resolution imaging techniques we show that the anchoring protein Gravin enhances the precision of cellular signaling at the spindle poles of cells undergoing mitosis. In particular, Gravin functions to assemble a kinase signaling scaffold that comprises of Aurora A and Polo-like kinase 1, two enzymes that govern passage through the mammalian cell cycle. More clinically relevant studies have discovered that aberrant Gravin signaling contributes to pathological changes in the mitotic index and polarized division of cancer cells in common germline derived tumors such as testicular seminomas.

Time and place: Oct 13, 2015 01:00 PM – 02:00 PM, Runde auditorium (R-105), Domus Medica tilbygg, Sognsvannsveien 9, Oslo.

About: Professor John D. Scott and his group are located at the Howard Hughes Medical Institute, Department of Pharmacology, University of Washington, Seattle, US. The Scott research group is interested in understanding the specificity of signal transduction events that are controlled by anchoring proteins. Anchoring proteins facilitate rapid signal transduction by optimally positioning protein kinases and phosphatases in the vicinity of their activating signals and close to their substrates.

Organized by: Biotechnology Centre / Centre for Molecular Medicine Norway (NCMM), UiO

Co-organized by: NBS-Oslo (BIG)

Contact: Kjetil Taskén, Professor of Medicine, M.D., Ph.D.